What are the application of IVIVC?

In vitro-in vivo correlation (IVIVC) models are having various applications. We are hereby listed IVIVC applications:

• Product development of new formulations, pre-formulation studies, laboratory scale trials.
• Optimization of the formulation/process predicted from the IVIVC validated.
• During scale-up the dissolution data are used to judge the impact of process changes as well establishing final specifications for dissolution.
• The database may possibly be utilized during further scale-up and site transfer as well as supporting post approval changes.
• Analysis of in vitro and in vivo data for the feasibility of an acceptable IVIVC.
• Design and analysis of clinical studies possibly needed for generating the IVIVC.
• Aid in the optimization of in vitro dissolution system to be a predictor of in vivo performance, i.e. selection of a biorelevant and discriminating method.
• Development and validation of Level A&C IVIVC models, including linear and nonlinear models.