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1 Apr 2019

How forced degradation can be achieved?

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Degradation can be achieved by exposing the drug, for extended period of time, to extremes of pH (HCl or NaOH solutions of different strengths), at elevated temperature, to hydrogen peroxide at room temperature, to UV light, and to dry heat (in an oven) to achieve degradation to an extent of 5–20%.

Generally, trial and error experimentation is used during these experiments.

This trial and error approach is generally cost, labor, and time intensive and should be substituted with some systematic approach.

From exhaustive literature, it was observed that experimental design in forced degradation experiments can be used to save cost and labor by avoiding trial and error experimentation

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