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11 Dec 2015

Case Study: Packaging Innovation as a part of product differentiating strategy in pharmaceuticals

Packaging Innovation plays vital role in preparing product differentiating strategy in pharmaceuticals.

Daiichi Sankyo Company, Limited (hereafter, Daiichi Sankyo) is introducing new generic drugs under generics subsidiary, Daiichi Sankyo Espha,

Product name

Therapeutic category

Original brand name

Naftopidil OD Tablets 25mg “DSEP”

Treatment for urination disorder due to enlargement of prostate

Flivas® OD Tablets
25mg, 50mg, 75mg

Naftopidil OD Tablets 50mg “DSEP”
Naftopidil OD Tablets 75mg “DSEP”
Metformin Hydrochloride Tablets 250mgMT “DSEP”

oral hypoglycemic agent

Metgluco® Tablets 250mg, 500mg

Metformin Hydrochloride Tablets 500mgMT “DSEP”
Letrozole Tablets 2.5mg “DSEP”

Aromatase inhibitor/
postmenopausal breast cancer treatment

Femara® Tablets 2.5mg

Oxaliplatin I.V. Infusion Solution

200mg “DSEP”

*Additional strength of formula released in 50mg, 100mg in Dec. 2014

Anti-malignant tumor agent

Elplat® I.V. Infusion Solution 200mg


Product attributes – Daiichi Sankyo Espha measures

Daiichi Sankyo Espha has continued to maintain a level of quality based on the quality management standards of the Daiichi Sankyo Group. Thanks to initiatives such as the world’s first double-sided printing on tablets, Daiichi Sankyo Espha has contributed to innovations in formulation and labeling to make drugs easier to ingest and harder for patients to mistakenly or incorrectly take. These kind of high value-added generic drugs are put forth by Daiichi Sankyo Espha as “premium generics.

Measures to prevent inadvertent ingestion by children

In order to respond to the risk of patient family members, particularly children, taking their medicine by mistake, a new measure has been introduced for Letrozole Tablets (postmenopausal breast cancer treatment).

– C-Guard

This PTP sheet was designed so that tablets can only be extracted if an inner sheet is slid up or down to match up with the position of the tablet, thus helping to prevent children taking the drug by mistake.

(Letrozode Tablets equipped with C-Guard protection)


Innovative design of PTP sheets and tablets

In order to prevent mistaken or inadvertent ingestion, innovations in formulation and labeling are continuing to be developed.

  • Easily recognizable original symbols:

PTP sheets feature original symbol marks based on formulation and disease characteristics.

  • GS1 data barcode for each tablet:

With the aim of helping to ensure there is no mistaken ingestion of tablets, GS1 data barcodes are printed on the back of PTP sheets.

  • Pitch control:

Clear identification of tablets by printing of product names, active ingredients, etc. in fixed positions.

  • Double-sided printing (Metformin Hydrochloride Tablets):

Printing of product name and active ingredient content on both sides of tablets to make them easier to distinguish.

  • Engraved markings (Naftopidil OD Tablets, Letrozole Tablets):

Code (NFP/LTZ) engraved on tablets to make them easier to distinguish.


Daiichi Sankyo Espha is a company that manufactures and markets generic drugs, accommodating rising demand based on the spirit of Daiichi Sankyo Group corporate philosophy* of supplying pharmaceuticals to address diverse medical needs. Daiichi Sankyo Espha strives to provide peace of mind for users by fulfilling the most important pharmaceutical criteria of quality, information, and stable supply while delivering the economic benefits of generics.

Additional Discussion:

What is PTP (Press Through Packages) Sheets?

  • PTP sheets are now mainstream of packaging for tablet / capsule medicines. PTP sheets assure the effectiveness, safety and stability of the pharmaceutical, enhance the protection and reliability, and well known for keeping the quality as packaging.

What is GS1 data barcode?

GS1 data barcode is a next generation barcode which has been in use as a global standard since 2010.

It has the merit of enabling management of product attributes such as manufacture lot and efficacy period.

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