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4 Jun 2021

Case study – Adagrasib out licensing deal

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Zai Lab said on Tuesday it has entered into a license agreement with Mirati Therapeutics to develop and commercialize Mirati’s KRAS G12C inhibitor adagrasib in greater China.

Under the agreement, Zai will pay $65 million upfront and Mirati will be eligible for another $273 million in potential milestone payments along with tiered royalties. The deal gives Zai the rights to develop and commercialize adagrasib in mainland China, Hong Kong, Macau, and Taiwan as a treatment for cancers characterized by KRAS G12C mutations.

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“Lung cancer is the most common cancer in China, and we aim to make adagrasib an important product in our growing lung cancer franchise,” Zai CEO Samantha Du said in a statement. “We are also excited about the potential of adagrasib to treat colorectal, pancreatic, and other cancers characterized by KRAS G12C mutations.”

Mirati has the option to co-commercialize adagrasib in greater China and retains exclusive rights to the drug in all other countries.

In March, Mirati presented data from a Phase I/II study of adagrasib in KRAS G12C-mutated non-small cell lung cancer. In the study, 45 percent of 51 evaluable patients had a partial response after treatment with adagrasib. Mirati is expecting to complete a new drug application submission for adagrasib in KRAS G12C-mutated NSCLC with the US Food and Drug Administration later this year.

Last month, Mirati also partnered with Qiagen to develop a tissue-based companion diagnostic to identify patients with the KRAS G12C mutation who are likely to respond to adagrasib.

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